It is common to send out automated mail with a From address that does not have an inbox that is checked by a human. To make this clear, such addresses are often of the form "noreply@example.org".

However, spam filters punish when a mail contains "noreply" in the Reply-To header (we have even seen bounces caused by this). Please allow setting different addresses for these headers, because they have distinct purposes, or allow disabling the Reply-To header entirely.